CLINICAL STUDIES
  1. Oxford Cognitive Comorbidity and Ageing Research (ORCHARD). A cohort study aiming to identify older hospital patients at high short-term risk of dementia and cognitive decline using routinely collected hospital electronic clinical and brain imaging data to improve care. Funded by NIHR i4i programme grant (NIHR 204290) on which I am a co-applicant. Study website ; NIHR website .
  2. Oxford Haemodynamic Adaptation to Reduce Pulsatility trial (OxHARP). A double-cross-over placebo controlled randomised clinical trial on the effects of two phosphodiesterase inhibitors (Sildenafil and Cilostasol) on cerebrovascular reactivity and the pulsatility of cerebral blood flow. Funded by Wellcome Trust. ClinicalTrials.gov: NCT03855332 ; Protocol ; Results
  3. Effects of Amlodipine and Other Blood Pressure Lowering Agents on Microvascular Function trial (TREAT@SVDs). A phase three cross-over trial of the effects of three commonly used anti-hypertensives (Amlodipine, Losartan, Atenolol) on endothelial function and cerebrovascular reactivity. Funded by the European Union’s Horizon 2020 programme. ClinicalTrials.gov: NCT03082014 ; Protocol ; Results
  4. Oxford Vascular Study (OxVASC). A cohort study of people at risk of stroke and vascular dementia. Study website .
  5. Arterial Pulsatility in Small Vessel Diseases – Measurement of Arterial Pulsatility on MRI (OxBP). A sub-study of the TREAT@SVDs trial investigating the effects of vasodilators on cerebral pulsatility.

PUBLICATIONS
  1. Webb AJS, Birks J, Feakins KA, Lawson A, Dawson J, Rothman AMK, Werring JD, Llwyd O, Stewart C, Thomas J. Cerebrovascular Effects of Sildenafil in Small Vessel Disease: The OxHARP Trial. Circulation Research 2024 Publication ahead of print.
  2. Kopczak A, Stringer MS, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Reyes CA, Garcia DJ, Onkenhout L, Wartolowska KA, Thrippleton MJ, Kampaite A, Duering M, Staals J, Lesnik-Oberstein S, Muir KW, Middeke M, Norrving B, Bousser MG, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M; TREAT-SVDs collaborators. Effect of blood pressure-lowering agents on microvascular function in people with small vessel diseases (TREAT-SVDs): a multicentre, open-label, randomised, crossover trial. Lancet Neurology 2023;22:991-1004.
  3. Kopczak A, Stringer M, van den Brink H, Kerkhofs D, Blair GW, van Dinther M, Onkenhout L, Wartolowska KA, Thrippleton MJ, Duering M, Staals J, Middeke M, André E, Norrving B, Bousser M-G, Mansmann U, Rothwell PM, Doubal FN, van Oostenbrugge R, Biessels GJ, Webb AJS, Wardlaw JM, Dichgans M, on behalf of the SVDs@target consortium. The EffecTs of Amlodipine and other Blood PREssure Lowering Agents on Microvascular FuncTion in Small Vessel Diseases (TREAT-SVDs) trial: Study protocol for a randomised crossover trial. European Stroke Journal 2022;8:387-397.
  4. Webb AJS, Wartolowska KA, Li L, Mazzucco S, Rothwell PM. Consistencies and differences in intermediate physiological phenotypes of vascular ageing between ischaemic stroke aetiologies. Cerebrovascular Diseases 2023;52(2):194-201.
  5. Webb AJS, Wartolowska KA, Li L, Rothwell PM. Low heart rate is associated with cerebral pulsatility after TIA or minor stroke. Annals of Neurology 2022;92:909-920.
  7. Webb AJS, Lawson A, Wartolowska KA, Mazzucco S, Rothwell PM. Aortic stiffness, pulse pressure and cerebral pulsatility progress despite best medical management: the OxVASC cohort. Stroke 2022;53:1310–1317.
  8. Wartolowska KA, Webb AJS. Big cohort studies offer insights into preventable risk factors. European Heart Journal 2021;42:4280–4281.
  11. Webb AJS, Lawson A, Wartolowska KA, Mazzucco S, Peter M Rothwell PM. Progression of Beat-to-Beat Blood Pressure Variability Despite Best Medical Management. Hypertension 2021;77:193-201
  13. Karaszewski B, Wardlaw JM, Marshall I, Cvoro V, Wartolowska K, Haga K, Armitage PA, Bastin ME, Dennis MS. Early brain temperature elevation and anaerobic metabolism in human acute ischaemic stroke. Brain 2009;32:955-964
  14. Cvoro V, Wardlaw JM, Marshall I, Armitage PA, Rivers CS, Bastin ME, Carpenter TK, Wartolowska K, Farrall AJ, Dennis MS. Associations between diffusion and perfusion parameters, N-acetyl aspartate, and lactate in acute ischemic stroke. Stroke 2009;40:767-772
  15. Karaszewski B, Wardlaw JM, Marshall I, Cvoro V, Wartolowska K, Haga K, Armitage PA, Bastin ME, Dennis MS. Measurement of brain temperature with magnetic resonance spectroscopy in acute ischemic stroke. Annals of Neurology 2006;60:438-446
  16. Marshall I, Karaszewski B, Wardlaw JM, Cvoro V, Wartolowska K, Armitage PA, Carpenter T, Bastin ME, Farrall A, Haga K. Measurement of regional brain temperature using proton spectroscopic imaging: validation and application to acute ischemic stroke. Magnetic Resonance Imaging 2006;24:699-706
  17. Wardlaw JM, Chappell FM, Best JJ, Wartolowska K, Berry E. NHS Research and Development Health Technology Assessment Carotid Stenosis Imaging Group. Non-invasive imaging compared with intra-arterial angiography in the diagnosis of symptomatic carotid stenosis: a meta-analysis. Lancet 2006;367:1503-1512
  18. Marshall I, Papathanasopoulou P, Wartolowska K. Carotid flow rates and flow division at the bifurcation in healthy volunteers. Physiological Measurement 2004;25:691-697

CONFERENCE PRESENTATIONS
  1. Wartolowska K and Webb AJS. Regional diffusion imaging changes related to obesity, after adjusting for other risk factors: the UK Biobank study. The 31th ISMRM Conference. London, UK. 2020.
  2. Wartolowska K and Webb AJS. Complex interactions between obesity and white matter: UK Biobank study. European Stroke Organisation Conference. Virtual due to COVID. 2021.
  3. Wartolowska K and Webb AJS. Effect of past and concurrent blood pressure above 120/70 on white matter hyperintensities: an analysis of the UK Biobank cohort. European Stroke Organisation-World Stroke Organisation Conference. Virtual due to COVID. 2021.
  4. Wartolowska K and Webb AJS. Differential associations between macroscopic and microstructural white matter injury with constant and pulsatile blood pressure components: an analysis of the UK Biobank cohort. European Stroke Organisation-World Stroke Organisation Virtual Conference. Virtual due to COVID. 2020.
  5. Croal PL, Ray KJ, Wartolowska K, Lawson A, Webb A, Jezzard P. Physiological correlates of brain pulsatility in cerebrovascular small vessel disease: a data-driven approach with high temporal resolution fMRI. ISMRM & SMRT Virtual Conference & Exhibition. 2020.
  6. Wartolowska K and Webb AJS. Mid-life diastolic blood pressure predicts excess future white matter hyperintensities more than systolic blood pressure: an analysis of the UK Biobank cohort. The Brain Prize Meeting: “Silently Loosing the Brain”. The Lundbeck Foundation. Copenhagen, Denmark. 2019.
  7. Cvoro V, Wardlaw JM, Wartolowska K , Farrall AJ, Marshall I, Armitage PA, Rivers CS, Bastin ME, Carpenter TK, Dennis MS. Lactate values in the acute stroke diffusion lesion vary with perfusion levels The 15th European Stroke Conference Brussels, Belgium. 2006.
  8. Wardlaw JM, Karaszewski BC, Marshall I, Cvoro V, Wartolowska K , Haga K, Armitage PA, Bastin ME. Dennis MS. Measurement of brain temperature with MR spectroscopy in patients with acute ischaemic stroke - temperature is highest in "penumbral" tissue British Society of Neuroradiologists Annual Scientific Meeting Edinburgh, UK. 2005.
  9. Marshall I, Karaszewski B, Wardlaw JM, Cvoro V, Wartolowska K , Armitage PA, Carpenter T, Bastin M, Farrall A, Haga K, Dennis M. Measurement of regional brain temperature using proton spectroscopic imaging: preliminary results in acute ischaemic stroke European Society for Magnetic Resonance in Medicine and Biology (ESMRMB) Conference, Basel Switzerland. 2005.