A three-arm, cross-over placebo-controlled trial on the modulation of pain processing, as measured using BOLD-FMRI and rsFMRI, by Pregabalin and Tramadol in patients with post-traumatic neuropathic pain. The study simulated "go/no-go" decision making in analgesic drug development.

The trial was funded by Pfizer and grants from the National Institute for Health Research Oxford Biomedical Research Centre, Medical Research Council of Great Britain and Northern Ireland, the Wellcome Trust, and the Innovative Medicines Initiative Joint Undertaking, under grant agreement no. 115007, resources of which are composed of financial contributions from the European Union’s Seventh Framework Programme (FP7/2007-2013) and European Federation of Pharmaceutical Industries and Associations companies’ in kind contribution.

I was involved in the development of the protocol and the statistical analysis plan and led the day-to-day management, acquired and analysed the data and wrote the original manuscript.

Psychobehavioural and FMRI analysis; Individual patient data secondary analysis of FMRI markers of analgesic treatment efficacy.